Disclosed herein are compositions that can form a covering, layer, film, device, and/or prosthetic skin that can be comfortably worn to provide skin barrier function, skin hydration and therapeutic and aesthetic benefits. Provided herein are novel compositions that have low tackiness and form quickly, resulting in a wearable, comfortable (maintains temperature and humidity), breathable, thin, optically invisible, cosmetically elegant, flexible, stretchable, elastic and body-movement conforming, yet long-lasting covering, layer, film, device, and/or prosthetic skin on the skin or any other body surface. Provided herein are novel compositions that can form a covering, layer, film, device, and/or prosthetic skin that works for extended periods in excess of about 24 hours, while retaining function during and after exercising, showering and swimming (in sea-water, fresh water and chlorinated water), steam room (heat at high humidity), and sauna (heat at low humidity).本文揭示可形成覆蓋物、層、膜、裝置及/或人工皮膚之組合物，該覆蓋物、層、膜、裝置及/或人工皮膚可舒適地穿戴以提供皮膚障壁功能、皮膚水合以及治療及美學益處。本文提供新穎組合物，其具有低黏性且迅速形成，從而在皮膚或任何其他身體表面上產生可穿戴、舒適(維持溫度及濕度)、透氣、較薄、光學不可見、化妝上優美、撓性、可伸展、彈性及身體運動順從性且持久性之覆蓋物、層、膜、裝置及/或人工皮膚。本文提供可形成覆蓋物、層、膜、裝置及/或人工皮膚之新穎組合物，該覆蓋物、層、膜、裝置及/或人工皮膚可在超過約24小時之延長時段內發揮作用，同時在運動、淋浴及游泳(在海水、淡水及氯化水中)、蒸汽室(高濕熱)及桑拿浴(低濕熱)期間及之後保留功能。
