Charlotte Hougaard;Dan Peters;Birgitte L. Eriksen;Palle Christophersen
发明人:
Birgitte L. Eriksen,Charlotte Hougaard,Dan Peters,Palle Christophersen
申请号：
US13120833
公开号：
US08268838B2
申请日:
2009.09.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are substituted purinyl-pyrazol derivatives of the following formula (I), or a pharmaceutically acceptable salt thereof, and their use as potassium channel modulating agents, as well as pharmaceutical compositions having such derivatives that are useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels:wherein R1 represents hydrogen or alkyl； one of R2, R3 and R4 represents alkyl, hydroxy-alkyl, alkoxy-alkyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy or alkoxy； and the other two of R2, R3 and R4, independently of each other, represent hydrogen, alkyl, hydroxy-alkyl, alkoxy-alkyl, halo, trifluoromethyl, trifluoromethoxy, hydroxy or alkoxy； R5 represents phenyl optionally substituted with one or more substituents selected from the group consisting of alkyl, halo, trifluoromethyl, trifluoromethoxy, alkoxy and cyano； and R6 represents R′OC(═O)—, wherein R′ represents alkyl, alkoxy, alkoxy-alkyl or adamantanyl.
