The Board of Regents of The University of Texas System;The Wistar Institute of Anatomy and Biology
发明人:
Shay, Jerry W.,Zhang, Gao
申请号：
AU2017271615
公开号：
AU2017271615A1
申请日:
2017.05.26
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure provide for methods of using 6-thio-2'-deoxyguanosine (6-thio- dG) to treat telomerase-positive cancers that exhibit (a) one or more TERT promoter mutations, and/or (b) enriched telomere transcriptional signature(s). In particular, melanomas, including those who are not sensitive or have become resistant to immune checkpoint inhibition and/or MAPKi therapy are targets for this therapy.
