PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACT OF SCHIZANDRA CHINENSIS AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
LEE, CHUL WOO;이철우;안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN, HO YONG,손호용,LEE, CHUL WOO,이철우
申请号：
KR1020120105630
公开号：
KR1020140043534A
申请日:
2012.09.24
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a health supplement for preventing or treating thrombosis which include extract of Schizandra chinensis as an active ingredient and, more specifically, to a pharmaceutical composition for preventing or treating thrombosis which includes ethanol extract of Schizandra chinensis as an active ingredient and a health supplement including the extract. The extract of Schizandra chinensis as the active ingredient of the pharmaceutical composition and health supplement for preventing or treating thrombosis is prepared, as being identified by an embodiment of the specification, by successively fractioning using hexene, ethyl acetate, and butanol after preparing the extract by extracting the Schizandra chinensis using ethanol and the likes. Ethyl acetate and butanol fraction, which show anticoagulation activities by enhanced direct inhibition of thrombin, inhibition of prothrombin, and inhibition of blood coagulation factors, can efficiently suppress blood coagulation and be used for preventing and treating thrombosis such as ischemic stroke and cerebral hemorrhage through blood flow Improvement. Specifically, the Schizandra chinensis extract of the present invention does not show acute oral toxicity, enhances thermal stability, does not lose anticoagulation effects under an acid condition of pH 2 and inside plasma so that the Schizandra chinensis extract can be prepared in various forms such as extract, powder, pill, tablet, and the likes and can be useful in pharmaceutical industries and food industries.본 발명은 오미자(Schizandrachinensis) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 오미자의 에탄올 추출물을 유효성분으로 함유하는 것을 특징으로 하는 혈전증의 예방 또는 치료용 약학적 조성물 및 상기 추출물을 포함하는 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 오미자 추출물은, 본 명세서의 실시예를 통해 증명된 바와 같이, 오미자를 에탄올 등으로 추출하여 추출물을 조제한 후, 헥센, 에틸아세테이트 및 부탄올을 이용하여 순차적으로 분획하여 조제되며, 이 중 우수한 트롬빈 직접저해, 프로트롬빈 저해 및 혈액응고인자 저해효과에 의한 항혈전
