PHARMACEUTICALLY ACCEPTABLE SALTS OF (E)-N-[4-[[3-CHLORO-4-(2-PYRIDYLMETHOXY)PHENYL]AMINO]-3-CYANO-7-ETHOXY-6-QUINOLYL]-3-[(2R)-1-METHYLPYRROLIDIN-2-YL]PROP-2-ENAMIDE, PREPARATION PROCESS AND PHARMACEUTICAL USE THERE OF
The present disclosure relates to the pharmaceutically acceptable salts of 6-amino quinazoline or 3-cyano quinoline derivatives, preparation processes and their use as a therapeutic agent. Specifically, the present disclosure relates to the pharmaceutically acceptable salts of (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl] amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide presented by formula (I), preparation processes and the uses for treatment especially for protein kinase inhibitors.本發明涉及6-胺基喹唑啉或3-氰基喹啉類衍生物的可藥用的鹽、其製備方法及其在醫藥上的應用。具體而言,本發明涉及式(I)所示的(E)-N-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]胺基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2R)-1-甲基吡咯烷-2-基]丙-2-烯醯胺的可藥用的鹽,其製備方法以及作為治療劑特別是作為蛋白激酶抑制劑的用途。
