A method for detecting fatigue is provided herein. The present invention includes the following steps: detecting a physiology feature sequence of a user in continuous time computing a linear regression slope and/or the differential thereof based on the physiology feature sequence and determining the fatigue of the user by analyzing the slop, the difference of slop and the durations of the slop as well as the difference of slop. A fatigue detecting device is also disclosed here. The present invention can be utilized to effectively detect the fatigue of the user.一種疲勞度偵測方法包括量測一使用者在一連續時間內的一生理特徵值序列,並依據此生理特徵值序列運算出一線性回歸斜率且/或線性回歸斜率之間之一差異值。再利用判斷線性回歸斜率及其持續時間長度判斷使用者之疲勞度。一種疲勞度偵測裝置亦於此處提出。本發明可有效偵測使用者之疲勞程度。S10,S20,S30,S40,S50‧‧‧步驟