SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4- {3-[CIS-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YL]PROPOXY} BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
ROBERT NICOLAS,로버트, 니콜라스,LERESTIF JEAN MICHEL,레레스티프, 장-미셸,LECOUVE JEAN PIERRE,레쿠브, 장-피에르,GAILLARD MARINA,겔라드, 마리나,MEUNIER LOIC,메우니어, 로익,LETELLIER PHILIPPE,레텔리어, 필립페,BOIRET MATHIEU,보이레트, 마티유
申请号：
KR1020120060635
公开号：
KR1020120136296A
申请日:
2012.06.05
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A method for synthesizing 4-{3-&lsqb；cis-hexahydrocylopenta &lsqb；c&rsqb； pyrrole-2(1h)-yl&rsqb；propoxy}benzamide hydrochloride is provided to ensure long-term storage without certain condition. CONSTITUTION: A method for industrially synthesizing a compound of chemical formula I comprises: a step of reacting a compound of chemical formula II with ammonium to prepare a compound of chemical formula III； a step of reducing the compound of chemical formula III to prepare a bicyclic amine of chemical formula IV； and a step of coupling the bicylic amine with a compound of chemical formula V under a basic condition, a step of performing reductive amination of the bicyclic amine.본 발명은 하기 화학식 (I)의 화합물의 산업적 합성 방법, 및 상기 화합물의 결정형 I, 및 상기 화합물의 관련된 유리 염기의 결정형 I, 및 상기 화합물의 약제로서의 용도에 관한 것이다:
