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Quinoline compound composing 1,2,4-triazine-dione and use thereof
专利权人:
发明人:
Hua Xu
申请号:
US14472439
公开号:
US08993566B2
申请日:
2014.08.29
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to a quinoline derivative represented by general formula (I) or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof wherein Ar, R1, R2, R3, X, Y and n have the meanings given in the description. The present invention also relates to the comparatively strong effect of the compound represented by general formula (I) on inhibiting c-Met kinase. The present invention further relates to the use of this compound or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof in the manufacturing of a medicament for treating the disease caused by abnormally over-expressing c-Met kinase, in particular, for treating or preventing cancer.
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