The present invention relates to compounds defined by formula Iwherein the variables R1x, R2x, R3x, R4x, R5x, R6x, R7x, RNx, R10x, Ax, Zx and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.本發明係關於由式I定義之化合物其中變數R1x、R2x、R3x、R4x、R5x、R6x、R7x、RNx、R10x、Ax、Zx及m如請求項1中所定義,其具有有價值之藥理學活性。特定言之,該等化合物為11-β-羥類固醇去氫酶1(11β-HSD1)之抑制劑,且因此適用於治療及預防可藉由抑制此酶影響之疾病,諸如代謝疾病,特定言之2型糖尿病、肥胖症及血脂異常。
