Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.本發明揭露抑制二醯基甘油醯基轉移酶2(DGAT2)活性之式I化合物及該式I化合物於治療動物的與該DGAT2相關之疾病的用途。