Graeme L. Fraser;Mark L. Peterson;Hamid R. Hoveyda
发明人:
Graeme L. Fraser,Hamid R. Hoveyda,Mark L. Peterson
申请号：
US13305349
公开号：
US20120071412A1
申请日:
2011.11.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective agonists of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Such compounds are useful as medicaments for treatment and prevention of a range of medical conditions characterized by disturbed gastrointestinal motility including, but not limited to, post-surgical gastroparesis and post-operative ileus in combination with opioid-induced bowel dysfunction. These agents are effective for multiple disorders at dose levels equivalent to those required to treat a single disorder.
