Larry Steffier,David Kurz,Robert B. Raney,Cary B. Robinson
申请号：
US11392024
公开号：
US08668930B2
申请日:
2006.03.29
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Provided is a slow-release delivery vehicle for delivering at least one active ingredient into a film coating, comprising a population of stable, homogeneously-dispersed, porous polymeric or co-polymeric beads having a network of pores, wherein the at least one active ingredient is held within the bead particles and within the network of pores and slowly released by internal flow, and wherein the network of pores is substantially non-collapsible upon removal of the active ingredient. The porous co-polymer bead preparation comprises a continuous aqueous phase solution containing a monomeric mixture of at least one polyvinylaromatic monomer and at least one porogen forming a network that comprising (i) macropores (ii) mesopores (iii) micropores and (iv) gel porosity. Also provided are methods of preparing the porous co-polymer bead preparation and for its use as a slow-release delivery vehicle.
