PCV-2 antigen-containing antigen preparations are being reduced composition comprising a PCV-2 antigen, and viral activity, as well as killing and the present invention provides a method of reducing the virucidal activity of the immunogenic composition. Furthermore, the present invention relates to a method for enhancing the immunogenicity of an immunogenic composition of the immunogenic composition comprising a PCV-2 antigen and immunogenicity are enhanced.本発明は、PCV-2抗原を含む組成物、並びに殺ウイルス活性が低下されてあるPCV-2抗原含有抗原調製物および免疫原性組成物の殺ウイルス活性を低下させる方法を提供する。さらにまた、本発明は、PCV-2抗原を含む免疫原性組成物および免疫原性が高められてある免疫原性組成物の免疫原性を高める方法にも関する。