Methods and processes for preparation and production of deuterated É-diphenylurea are disclosed. Especially, a kind of deuterated É-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N- d3 -methylcarbamoyl)-4-pridinylox y)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.
