method for preparing n- (4-chloro-3- (trifluoromethyl) phenyl) -N '- (4- (2- (n- (methyl-d3) amino formyl) -4-pyridyloxy) phenyl) urea, intermediate, method to prepare 4-chloro-pyridyl-2- (n- (methyl-d3)) carboxamide, use of the intermediate and p-toluene sulfonate deuterated β-diphenyl urea compound

• 收藏
• 分享

专利权人:

LTD;SUZHOU ZELGEN BIOPHARMACEUTICAL CO.

发明人:

WEIDONG FENG,XIAOJUN DAI,XIAOYONG GAO

申请号：

BR112012023525

公开号：

BR112012023525A2

申请日:

2011.03.17

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

Methods and processes for preparation and production of deuterated É-diphenylurea are disclosed. Especially, a kind of deuterated É-diphenylurea compounds which can inhibit phosphokinase and the preparation method of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N- d3 -methylcarbamoyl)-4-pridinylox y)phenyl)urea are disclosed. The said deuterated diphenylurea compounds can be used for treating or preventing tumors and relative diseases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/