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Methods of administering epothilone analogs for the treatment of cancer
专利权人:
BRISTOL-MYERS SQUIBB COMPANY
发明人:
BANDYOPADHYAY REBANTA,MALLOY TIMOTHY M.,PANAGGIO ANDREA,RAGHAVAN KRISHNASWAMY SRINIVAS,VARIA SAILESH AMILAL,VARIA
申请号:
SK8562003
公开号:
SK288098B6
申请日:
2002.01.22
申请国别(地区):
SK
年份:
2013
代理人:
摘要:
It is described epothilone analog of the formula (II) for parenteral administration. The process of preparation thereof comprises the following steps providing that they are carried with protection from light: (a) dissolving of the epothilone analog in a mixture of at least 50 % by volume tertiary-butanol in water preparing a solution; (b) the resulting solutions is primarily dried at temperature from - 10øC to - 40 øC under the conditions of high vacuum during 24 to 96 hours producing lyophilized product; and (c) secondary drying of the resulting lyophilized product is performed at temperature 10 to 30 øC under the conditions of high vacuum during 24 to 96 hours. Pharmaceutical preparation containing the epothilone analog and method of production of the preparation are also described.It is described epothilone analog of the formula (II) for parenteral administration. The process of preparation thereof comprises the following steps providing that they are carried with protection from light: (a) dissolving of the epothilone analog in a mixture of at least 50 % by volume tertiary-butanol in water preparing a solution; (b) the resulting solutions is primarily dried at temperature from - 10řC to - 40 řC under the conditions of high vacuum during 24 to 96 hours producing lyophilized product; and (c) secondary drying of the resulting lyophilized product is performed at temperature 10 to 30 řC under the conditions of high vacuum during 24 to 96 hours. Pharmaceutical preparation containing the epothilone analog and method of production of the preparation are also described.
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