MIRALLES, Ricardo,NONELL, Santiago,RAGA, Manuel M.,GIUGLIETTA, Antonio,TEIXIDO, Jordi
申请号：
ES06725177
公开号：
ES2642842T3
申请日:
2006.03.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Benzoic acid ester compounds of formula (I): ** (See formula) ** where R1-R5 are independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy , hydroxy, amino, C1-C6-amino alkyl, C1-C6-amino dialkyl, wherein said two alkyl portions of said dialkylamino can form, together with the nitrogen atom to which they are attached, a heterocycle selected from pyrrolidine, piperidine , morpholine and piperazine optionally N-substituted with C1-C6 alkyl or C3-C6 cycloalkyl, C3-C6-cycloalkyl, C1-C6 alkyl-C3-C6-amino alkyl and C3-C6-amino dicycloalkyl, or two carbon groups adjacent ring forms a fused O- (CH2) mO group where m is 1 or 2, or two adjacent ring carbon groups form a CH>； = CH-CH>； = CH fused group； R is a group selected from (i), (ii) and (iii): ** (See formula) ** where R 'is selected from hydrogen, C1-C6 alkyl and C3-C6 cycloalkyl； R6-R10 are independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy, hydroxy, amino, C1-C6-amino alkyl, C1-C6-amino dialkyl, wherein said two alkyl portions of said dialkylamino may form, together with the nitrogen atom to which they are attached, a heterocycle selected from pyrrolidine, piperidine, morpholine and piperazine optionally N-substituted with C1-C6 alkyl or C3-C6 cycloalkyl, C3- cycloalkyl C6-amino, C1-C6 alkyl-C3-C6-amino alkyl and C3-C6-amino dicycloalkyl, or two adjacent ring carbon groups form a fused O- (CH2) group where n is 1 or 2, or two adjacent ring carbon groups form a group CH>； = CH-CH>； = CH fused； R11 is selected from hydrogen, C1-C6 alkyl and C3-C6 cycloalkyl； R12 is selected from hydrogen, C1-C6 alkyl and C3-C6 cycloalkyl； R13 and R14 are independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C3-C6 cycloalkoxy, hydroxy, amino, C1-C6-amino alkyl, C1-C6-amino dialkyl, wherein said two alkyl portions of said dialkylamino may form, together with the nitrogen atom to which they are attached, a hete
