PROBLEM TO BE SOLVED: To provide a β-secretase inhibitor that is highly safe and has excellent inhibitory action against β-secretase activity and food and drink comprising the β-secretase inhibitor.SOLUTION: The βsecretase inhibitor comprises one or more curcuminoid selected from the group consisting of curcumin 1, curcumin 2 and curcumin 3 as an active ingredient.SELECTED DRAWING: None