The present invention relates to an asymmetric siRNA which inhibits an expression of male pattern hair loss target genes and a use thereof and, more particularly, to an asymmetric siRNA which inhibits an expression of 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) gene, 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) gene or androgen receptor (AR) gene, and a composition for prevention or treatment of hair loss comprising the asymmetric siRNA.La présente invention concerne un petit ARNi asymétrique qui inhibe une expression de gènes cibles de perte de cheveux masculine et son utilisation et, plus précisément, un petit ARNi asymétrique qui inhibe l'expression du gène de la 3-oxo-5-alpha-stéroïde 4-déshydrogénase 1 (SRD5A1), du gène de la 3-oxo-5-alpha-stéroïde 4-déshydrogénase 2 (SRD5A2) ou du gène du récepteur des androgènes (AR), et une composition destinée à la prévention ou au traitement de la perte de cheveux comprenant le petit ARNi asymétrique.본 발명은 남성형 탈모 표적 유전자의 발현을 억제하는 비대칭 siRNA 및 이의 용도에 관한 것으로, 구체적으로는 SRD5A1 (3-oxo-5-alpha-steroid 4-dehydrogenase 1) 유전자, SRD5A2 (3-oxo-5-alpha-steroid 4-dehydrogenase 2) 유전자 또는 AR (Adrogen receptor) 유전자의 발현을 억제하는 비대칭 siRNA 및 상기 비대칭 siRNA를 포함하는 탈모 예방 또는 치료용 조성물에 관한 것이다.
