John A. McCauley,Christian Beaulieu,David Jonathan Bennett,Christopher J. Bungard,Sheldon Crane,Thomas J. Greshock,Katharine M. Holloway,Daniel McKay,Carmela Molinaro,Oscar Miguel Moradei,Satyanarayan
申请号:
US15104510
公开号:
US20160311786A1
申请日:
2014.12.17
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention is directed to 2,5,6-substituted morpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.