BARBANTI, ELENA,CACCIA, CARLA,SALVATI, PATRICIA,VELARDI, FRANCESCO,RUFFILLI, TIZIANO,BOGOGNA, LUIGI
申请号：
CA2653012
公开号：
CA2653012C
申请日:
2007.06.08
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A process for obtaining therapeutically active 2-[4-(3- and 2- (fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2- [4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.
