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FORME CRISTALLINE D'UN INHIBITEUR DE LA TYROSINE KINASE DE BRUTON (BTK) ET SON PROCEDE DE PREPARATION
专利权人:
JIANGSU HENGRUI MEDICINE CO.; LTD.
发明人:
WU, GUAILI,QIU, ZHENJUN,LU, XI,LU, YUN
申请号:
CA3009256
公开号:
CA3009256A1
申请日:
2016.12.20
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
The present invention relates to a crystalline form of a BTK kinase inhibitor and the preparation method thereof. In particular, the present invention relates to a type I crystal of (R)-1-(3-(4-amino-3-(4-(2,6-difluorophenoxy)phenyl)-7-hydroxy-1H-pyrorolo[2,3-d]pyridaz-1-yl)pyrrolidin-1-yl)butyl-2-alkyne-1-ketone (the compound in formula (I)) and the preparation method thereof. The type I crystal of the compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the crystal solvent used has a low toxicity and residue, thus making same more suitable for use in clinical treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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