PROBLEM TO BE SOLVED: To provide a "Tyrosinase inhibitor" comprising an ingredient isolated and obtained from Rosa of a plant raw material, and to provide a manufacturing method thereof.SOLUTION: When an ingredient distilled by dry distillation of a plant raw material in a moisture state, under low temperature and reduced pressure condition using dry distillation apparatus with a decompression mechanism is called "a part of a low-temperature and decompression dry distillation distillate (d)" and a solid or solid state residue remaining in the dry distillation apparatus after a low-temperature and decompression dry distillation operation thereof is called a "low-temperature and decompression dry distillation residue (R)", the plant raw material is Rosa, and a tyrosinase inhibitor contains as an active ingredient the "low-temperature and decompression dry distillation residue (R) as it is" or a "extract (E) with a solvent from the low-temperature and decompression dry distillation residue (R)".
