COMPOSÉ D'INDOCYANINE, PROCÉDÉ DE SYNTHÈSE DE CELUI-CI, PROCÉDÉ DE PURIFICATION DE CELUI-CI, COMPOSITION DIAGNOSTIQUE UTILISANT UN COMPOSÉ D'INDOCYANINE, ET DISPOSITIF POUR MESURER UNE CINÉTIQUE IN VIVO ET DISPOSITIF POUR VISUALISER LA CIRCULATION UTILISANT LA COMPOSITION DIAGNOSTIQUE
National University Corporation Mie University;National University Corporation Nagoya University
发明人:
申请号：
EP11736813.4
公开号：
EP2530093B1
申请日:
2011.01.28
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.
