NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY;CLIO, INC.;TOHOKU UNIVERSITY
发明人:
Mari Dezawa,Yoshinori Fujiyoshi,Masanori Yoshida
申请号：
US15238020
公开号：
US10034889B2
申请日:
2016.08.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to damage, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to damage, the composition including S1P as an active ingredient.
