CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY;MIRRX THERAPEUTICS A/S;UNIVERSITY OF SYDNEY
发明人:
GAMBLE, Jennifer,MOLLER, Thorleif,VADAS, Mathew
申请号：
HK18115461
公开号：
HK1256371A1
申请日:
2018.12.04
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
The present invention provides methods for increasing the sensitivity of a tumour to immunotherapy, chemotherapy or radiotherapy by administering an effective amount of an oligonucleotide that inhibits the binding of miR-27a, or a variant thereof, to its target mRNA. Oligonucleotides used in the invention are typically in the form of a blockmirs used as an adjunctive therapy to inhibit tumour growth, normalise and/or improve function of tumour vasculature, and/or promote immune cell infiltration of tumours.
