Provided herein are composition for sensitizing tumors to anti-tumor therapies. The compositions include antisense oligonucleotides against TGFβ2, wherein the compositions sensitize tumors to anti-tumor therapies. Also provided herein are methods for treating cancer using the compositions described herein.本文提供用於使腫瘤對抗腫瘤治療敏感之組合物。該等組合物包括針對TGFβ2之反義寡核苷酸,其中該等組合物使腫瘤對抗腫瘤治療敏感。本文亦提供使用本文所述之組合物治療癌症之方法。