Ryan White,Yuan Cheng,Ana Elena Minatti,Bryant Yang,Xiao Mei Zheng,Patricia Lopez,Jason B. Human,Oleg Epstein,Ted Judd,Kelvin Sham,Qiufen Xue
申请号：
US14346252
公开号：
US09296759B2
申请日:
2012.09.21
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimers disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, L, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimers Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.
