THE BROAD INSTITUTE, INC.;THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE;DANA-FARBER CANCER INSTITUTE;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
SHAMJI, ALYKHAN,SUNDBERG, THOMAS,GRAY, NATHANAEL,XAVIER, RAMNIK,SCHREIBER, STUART L.,CHOI, HWAN, GEUN,LIANG, YANKE
申请号：
CA2955082
公开号：
CA2955082A1
申请日:
2015.08.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III -A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).
