Isaac S. Carrico,Brian L. Carlson,Peng Wu,Carolyn Ruth Bertozzi
申请号：
US16169292
公开号：
US10745464B2
申请日:
2018.10.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.
