Aldehyde tags, uses thereof in site-specific protein modification

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专利权人:

The Regents of the University of California

发明人:

Carlson, Brian L.,Bertozzi, Carolyn,Carrico, Isaac S.,Wu, Peng

申请号：

AU2007297661

公开号：

AU2007297661B2

申请日:

2007.09.19

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The invention features compositions and methods for site-specific modificationof proteins by incorporation of an aldehyde tag. Enzymatic modification at asulfatase motif of the aldehyde tag through action of a formylglycine generatingenzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moietyof FGly residue can be exploited as a chemical handle for site-specific attachmentof a moiety of interest to a polypeptide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/