ФАРБЕР, БОРИС СЛАВИНОВИЧ;ФАРБЕР, СОФЬЯ БОРИСОВНА;БОРИС СЛАВИНОВИЧ;СОФЬЯ БОРИСОВНА
发明人:
Фарбер, Борис Славинович,Фарбер, Софья Борисовна,Мартынов, Артур Викторович,Борис Славинович,Софья Борисовна,Артур Викторович
申请号：
EA202090756
公开号：
EA202090756A1
申请日:
2017.06.16
申请国别(地区):
EA
年份:
2020
代理人:
摘要：
The invention relates to organic and bioorganic, combinatorial chemistry, in particular to new combinatorial libraries of derivatives of oligopeptides and supramolecular structures based on them, which when used without separation into individual components possess powerful antiviral properties. The basis of the invention is the task of synthesizing combinatorial derivatives of oligopeptides with antiviral properties and with a new mechanism of action, the use of which will significantly increase the effectiveness of treatment and reduce the treatment time for viral diseases, such as influenza, herpes virus infections. The problem is solved by synthesizing combinatorial derivatives of oligopeptides with antiviral properties, characterized in that the combinatorial derivatives of oligopeptides, in the structure of which the amino group residues of lysines, histidines, arginines are accessible for modification, as well as the alcohol residues of threonine and serine available for modification, are simultaneously combinatorially modified by at least two various covalent modifiers and the resulting combinatorial mixture as a whole without purification and without isolation of each individual derivative is used as an antiviral agent in various pharmaceutical compositions. Modified complementary protected oligopeptides with powerful antiviral properties are proposed, on the basis of which a medicinal, veterinary or cosmetic preparation with a wide spectrum of activity can be obtained. The tool has a wide spectrum of action, is slightly toxic and is available for industrial production.Изобретение относится к органической и биоорганической, комбинаторной химии, а именно к новым комбинаторным библиотекам производных олигопептидов и супрамолекулярным структурам на их основе, которые при использовании без разделения на отдельные компоненты обладают мощными противовирусными свойствами. В основу изобретения поставлена задача синтезировать комбинаторные производные олигопептидов
