Pablo Caviedes;Paul R. Sanberg;THOMAS B. FREEMAN;Raul Caviedes;Don F. Cameron
发明人:
THOMAS B. FREEMAN,Pablo Caviedes,Raul Caviedes,Paul R. Sanberg,Don F. Cameron
申请号：
US13267346
公开号：
US20120148540A1
申请日:
2011.10.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.
