Moses Rodriguez,Allan J. Bieber,Arthur E. Warrington, Jr.,Meghan McGee Painter,Eric M. Poeschla
申请号：
US14156275
公开号：
US09421242B2
申请日:
2014.01.15
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods for increasing expression of an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide in mammals using a lentiviral vector comprising nucleic acid encoding a picornavirus 3Dpol polypeptide (or a fragment thereof) are provided.
