IWAKI, YUKI,KAWANAMI, TOSHIO,KSANDER, GARY MICHAEL,MOGI, MUNETO
申请号：
NZ59913610
公开号：
NZ599136A
申请日:
2010.11.18
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
599136 Disclosed are carbamoyl substituted biphenyl compounds of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: (S)-2-[(S)-2-(3'-chloro-biphenyl-4-yl)-1-(1H-tetrazol-5-ylcarbamoyl)-ethoxy]-propionic acid ethyl ester； (S)-2-[(S)-2-(3'-chloro-biphenyl-4-yl)-1-(1H-tetrazol-5-ylcarbamoyl)-ethylamino]-propionic acid； (S)-2-[(S)-2-(3'-Chloro-biphenyl-4-yl)-1-(3-hydroxy-isoxazol-5-ylcarbamoyl)-ethylamino]propionic acid. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for the treatment of a disorder or disease associated with neutral endopeptidase EC. 3.4. 24.11. activity； or for diseases or disorders such as hypertension, pain, inflammation and asthma.
