The present invention relates to antibody, the pharmaceutical composition comprising the antibody and the methods that the antibody is used alone or in combination of anti-human transforming growth factor β receptor II (TGF β RII), such as with what treating cancer and fibrosis.本發明涉及抗人轉化生長因子β受體II(TGFβRII)的抗體、包含該抗體的藥物組合物以及單獨或組合使用該抗體的方法,例如用於治療癌症和纖維化。