The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Ntls), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.本發明係關於一種抗體或其片段，其包含至少一個合併在該抗體或其片段之至少一個CDR區內之異源胺基酸序列，其中該至少一個異源胺基酸序列包含N端連接子序列(Ntls)、心房利尿鈉肽(ANP)及C端連接子序列(Ctls)。視情況地，該至少一個CDR區的至少一部分由合併在其中的該至少一個異源胺基酸序列置換。本發明亦係關於此類抗體或其片段在治療方法中之用途、包含此類抗體或其片段之組合物、編碼此類抗體或其片段之核酸或核酸混合物、包含此類核酸或此類核酸混合物之宿主細胞及用於製備此類抗體或其片段之方法。
