MAY, CHAD,DUBRIDGE, ROBERT B.,VINOGRADOVA, MAIA,PANCHAL, ANAND
申请号：
CA3075034
公开号：
CA3075034A1
申请日:
2018.09.06
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The invention relates to COnditional Bispecific Redirected Activation constructs, or COBRAs, that are administered in an active pro-drug format. Upon exposure to tumor proteases, the constructs are cleaved and activated, such that they can bind both tumor target antigens (TTAs) as well as CD3, thus recruiting T cells expressing CD3 to the tumor, resulting in treatment.
