BARTKOVITZ, DAVID JOSEPH,CHU, XIN-JIE,VU, BINH THANH,ZHAO, CHUNLIN,FISHLOCK, DANIEL
申请号：
PE2014001419
公开号：
PE20142185A1
申请日:
2013.03.12
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound of formula I, in which X is h, F, Cl, etc.； Z is low oxygen； R1 is low-level tar, low calcium, arilo, etc.； R2 is substituted phenyl； R3 is h, low-level or low-level substituted tar； R4 is removed from II, in which R5 is low-level and heterocyclic. Cyclopropene plus others, R6 is h or benzene. The most popular compounds are: 4 - ((2R, 3S, 4R, 5S) - 3 - (3-chloro-2-fluorophenyl) - 4 - (4-chloro-2-fluorophenyl) - 4-cyano-5-neopentylpyridine-2-carboxamido) - 3-methoxybenzoic acid 1 - (ethyl (isopropyl) amino) ethyl；4 - [(2R, 3S, 4R, 5S) - 3 - (3-chloro-2-fluoro-phenyl) - 4 - (4-chloro-2-fluoro-phenyl) - 4-cyano-5 - (2, 2-dimethyl-propyl) - pyridine-2-carbon] - amino} - 3-methoxy-benzoic acid, dibutylox-p-hydroxy, etc. He also mentioned a pharmaceutical composer This compound is an inhibitor of MDM2 and is useful in cancer treatment.SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: X ES H, F, CL, ENTRE OTROS； Y ES H, F, CL, ENTRE OTROS； Z ES ALCOXI INFERIOR； R1 ES ALQUILO INFERIOR, ALQUENILO INFERIOR, ARILO, ENTRE OTROS； R2 ES FENILO SUSTITUIDO； R3 ES H, ALQUILO INFERIOR O ALQUILO INFERIOR SUSTITUIDO； R4 SE ELIJE DE II, DONDE R5 ES ALQUILO INFERIOR, HETEROCICLO, CICLOALQUILO ENTRE OTROS Y R6 ES H O BENCILO. SON COMPUESTOS PREFERIDOS: 4-((2R,3S,4R,5S)-3-(3-CLORO-2-FLUORFENIL)-4-(4-CLORO-2-FLUORFENIL)-4-CIANO-5-NEOPENTILPIRROLIDINA-2-CARBOXAMIDO)-3-METOXIBENZOATO DE 1-(ETIL(ISOPROPIL)CARBAMOILOXI)ETILO； 4-{[(2R,3S,4R,5S)-3-(3-CLORO-2-FLUOR-FENIL)-4-(4-CLORO-2-FLUOR-FENIL)-4-CIANO-5-(2,2-DIMETIL-PROPIL)-PIRROLIDINA-2-CARBONIL]-AMINO}-3-METOXI-BENZOATO DE DI-TERT-BUTOXI-FOSFORILOXIMETILO； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LA MDM2 Y ES UTIL EN EL TRATAMIENTO DEL CANCER.
