Non-invasive methods for accurately classifying Coronary Artery Disease (CAD) is a challenging task. In the present disclosure, a two stage classification is performed. In the first stage of classification, a metadata based rule engine is utilized to classify a subject into one of a confirmed CAD subject, a CAD subject and a non-CAD subject. Here, a set of optimal parameters are selected from a set of metadata associated with the subject based on a difference in frequency of occurrence of the CAD among a disease population and a non-disease population. Further, an optimal threshold associated with each optimal parameter is calculated based on an inflexion based correlation analysis. Further, the CAD subject, classified by the metadata based rule engine is further reclassified in a second stage by utilizing a set of cardiovascular signal into one of the CAD subject and the non-CAD subject.
