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Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
专利权人:
Vanitha Ramakrishnan
发明人:
Vanitha Ramakrishnan,David Powers,Dale E. Johnson,Ursula Jeffry,Vinay Bhaskar
申请号:
US13009757
公开号:
US08309084B2
申请日:
2011.01.19
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.
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