Arthur E. Frankel,Yunpeng Su,Brad St. Croix,Stephen H. Leppla
申请号：
US13884899
公开号：
US09309322B2
申请日:
2011.11.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.
