PLONSKA-OCYPA KATARZYNA,PLUM LORI A,SIBILSKA IZABELA,BARYCKA KATARZYNA M,CLAGETT-DAME MARGARET,BARYCKI RAFAL,DELUCA HECTOR F,SICINSKI RAFAL R
申请号：
NZ59921610
公开号：
NZ599216A
申请日:
2010.09.30
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein are 1-desoxy-2-methylene-19-nor-vitamin D analogs represented by structural formula (Ia), and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor- vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
