Rafal R. Sicinski;Hector F. DeLuca;Rafal Barycki;Margaret Clagett-Dame;Katarzyna Plonska-Ocypa;Izabela Sibilska;Lori A. Plum;Katarzyna M. Barycka
发明人:
Hector F. DeLuca,Katarzyna M. Barycka,Izabela Sibilska,Lori A. Plum,Margaret Clagett-Dame,Rafal Barycki,Rafal R. Sicinski,Katarzyna Plonska-Ocypa
申请号：
US12895478
公开号：
US08642579B2
申请日:
2010.09.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention discloses 1-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
