The present invention relates topro-coagulant human Protein Sinhibitors, such as antibodies or antigen-binding fragments thereof that can be administered subcutaneously as prophylactic treatment for haemophilia patients regardless of inhibitor status and without interfering with non-coagulant functions of Protein S.本發明係關於促凝血人類蛋白質S抑制劑,諸如可在不考慮抑制劑狀況且不干擾蛋白質S之非凝血功能的情況下作為血友病患者之預防性治療皮下投予的抗體或其抗原結合片段。