PROBLEM TO BE SOLVED: To provide a novel pharmacological use of proteoglycan.SOLUTION: An advanced glycation end product production inhibitor comprises aquatic organism cartilage-derived proteoglycan of 0.000625 mass% or more and 0.04 mass% or less, and blueberry extract of 0.005 mass% or more and 0.08 mass% or less.SELECTED DRAWING: None【課題】プロテオグリカンの新規な薬理用途を提供する。【解決手段】終末糖化産物産生抑制剤は、水棲生物の軟骨由来のプロテオグリカンを0.000625質量%以上0.04質量%以下、及び、ブルーベリーエキスを0.005質量%以上0.08質量%以下の量で含む。【選択図】なし