A surgical stapling instrument (100) comprising a handle (160) comprising a trigger; a shaft (110), a plurality of staple cartridges (130) positioned within said shaft, wherein each said staple cartridge comprises a cartridge body (132) and a plural-ity of staples (190); a jaw (121) configured to receive a staple cartridge, a plurality of staple drivers (180) positioned within the jaw configured to eject staples from the staple cartridge, and a firing member (170) configured to engage the staple drivers as the firing member is advanced from an unfired position to a fired position, the instrument further comprising a cartridge driver (140) configured to sequentially advance a said staple cartridge (130) into the channel (122) of the jaw (121).