University of Pittsburgh- Of the Commonwealth System of Higher Education
发明人:
申请号：
EP16871478.0
公开号：
EP3383471A4
申请日:
2016.12.01
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided herein are methods of nerve blockage, for example for treatment of obesity, heart failure, cardiovascular disease, muscle spasms, chronic pain, or urinary retention in a patient. The method comprises first heating a nerve above physiological temperature (e.g. 37° C. in a human), such as from 43° C. to 54° C. for a duration that leads to reversible nerve blockage as opposed to nerve damage. Second, reversible nerve blockage is produced by cooling the nerve below physiological temperature to a temperature in which reversible nerve blockage is achieved, for example from 15° C. to 30° C.
