The invention relates to a device for generating a pulsed electromagnetic field with pulse control, wherein the pulses provided by the pulse generator represent periodic pulses having ascending and descending envelope curves with harmonic or anharmonic oscillation profile within the envelope curves, the pulse sequence is in the range of from 1 pulse/20 minutes to 10 pulses/minute, with pulse sequence, pulse function type and electromagnetic flux density being controlled via values which, obtained using non-invasive measuring methods on a target tissue, represent features of the blood microcirculation, with exponential functions as pulse function type being excluded. Greater and longer-lasting improvements of the microcirculation are achieved.