Oncolytic adenoviruses with increased proportion of the 156R splicing isoform of the E1 B protein

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专利权人:

Ixogen Ltd

发明人:

Oberg, Hans Daniel

申请号：

AU2013350929

公开号：

AU2013350929A2

申请日:

2013.11.29

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The invention relates to a recombinant adenovirus that has an oncolytic effect in a cancer cell. By modulating the level and type of splice isoforms of the E1B gene product, expressed from the E1B gene, the oncolytic activity of such viruses can be enhanced. The invention provides a recombinant adenovirus in which the proportion of the E1B-156R isoformis increased relative to wild-type levels. Such a recombinant adenovirus may selectivity replicate in cancer cells, thereby killing cancer cells whilst sparing normal cells.

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中国工程科技知识中心

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